At the American Association for Cancer Research’s annual meeting, Bristol-Myers Squibb announced that 34% of patients in its phase 1 trial of Opdivo were still alive five years later. That may not sound like a lot, but prior to the introduction of cancer immunotherapies, the average survival period for advanced melanoma patients was only 11 months. 7. Keytruda’s response rate in first-line NSCLC is phenomenal Opdivo may have had a banner year with its long-term advanced melanoma data, but Bristol-Myers’ key cancer drug flopped in a first-line advanced non-small cell lung cancer (NSCLC) study. That wasn’t the case for rival cancer immunotherapy Keytruda, which was developed by Merck (NYSE: MRK). In first-line advanced NSCLC patients whose tumors had at least 50% PD-L1 expression, the Keytruda arm had a 50% reduction in the risk of progression or death compared to chemotherapy, and a 40% decrease in the risk of death compared to chemotherapy. Furthermore, overall response rates jumped to 45% from just 28% with chemotherapy. For patients whose tumors have high PD-L1 expression, Keytruda has become a source of new hope. Image source: Getty Images. 8.
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More Jose Mourinho has lauded the in-form Zlatan Ibrahimovic as undroppable and a “great example” to his Manchester United team-mates. The Swede has scored eight goals in his last eight matches to help United progress in the Europa League and EFL Cup, as well as keep them in touch with the Premier League’s top four. At 35, Ibrahimovic is one of the more senior figures at Old Trafford and Mourinhois impressed by the striker’s all-round application. “He’s doing phenomenal and [on Saturday]he’s going to http://huntercarterland.boxcrack.net/2016/10/05/some-new-guidance-on-deciding-upon-vital-criteria-of-curriculum-vitae play again,” said the Portuguese when asked if it was almost impossible to drop Ibrahimovicahead of the weekend trip to West Brom. “He’sa greatexample to be honest, in every aspect, he’s very professional. Even when it’s difficult in today’sfootball players’ lives he keepshis family life private. “He’s a great example in everything. When you have him and [Michael] Carrick at 35 years old, I think the kids couldn’t have better players to look at.” United have won back-to-back league games for the first time since August to sit six points off the top four and Mourinho knows the busy festive period is key to their ambitions this season. “What we have to try to do in these three remaining matches [in December] is be in a position that gives us a chance in the second part of the season,” he said.
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