Both vaccines utilize an antigen called Factor H-binding protein (FHbp). The FHbp antigen in the vaccines binds with human Factor H (fH), which is a protein normally present in the bloodstream. FHbp specifically binds human and some non-human primate FH proteins. The investigators hypothesized that binding of FH to the vaccine depress protective antibody responses, which they had previously found in a model with mice that made human FH. In the new study, the researchers immunized infant rhesus macaques with either a conventional recombinant FHbp antigen that bound FH (similar to the antigens used in current meningococcal B vaccines), or a mutant antigen with 2 amino acid substitutions that eliminated binding of FH. The mutant antigen gave up to 15-fold greater protection as defined by the ability of the antibodies in the bloodstream to kill the bacteria. Replacing FHbp antigens in the currently licensed meningococcal B vaccines with a mutant low-FH binding antigen should enhance protective antibody responses. This is especially important given the results of a recent study published in the New England Journal (Basta et al, 375:220-228, 2016) that found that a third of students immunized with a meningococcal B vaccine to control an outbreak on a college campus failed to develop protective antibodies. “With 15 fold higher protective antibody response to the new mutant FHbp antigen, our results have the potential to lead to greatly improved meningococcal vaccines that can effectively target more strains of the bacteria.” Also, the new mutant vaccine was protective in monkeys as young as 3 months of age and, thus, has the potential to confer protection to human infants who in the age are most vulnerable to disease and for whom currently there is no vaccine. ### About UCSF Benioff Children’s Hospital Oakland UCSF Benioff Children’s Hospital Oakland (formerly Children’s Hospital & Research Center Oakland) is a premier, not-for-profit medical center for children in Northern California, and is the only hospital in the East Bay 100% devoted to pediatrics. UCSF Benioff Children’s Hospital Oakland affiliated with UCSF Benioff Children’s Hospital San Francisco on January 1, 2014.
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Thus, the dog faints and collapses at times. A List of Different Kinds of Doctors You Must Know About Who would not be happy if an M.D. appears after his name? She played a vital role during the rubella pandemic during the year 1964-65, treating patients both young and old who suffered from the devastating effects of the disease. An echo cardiogram will also help in evaluation of the cardiac function of the underlying heart disease. There are a few factors that will decide the time a patient will spend in the hospital. websitesOnce you complete your residencies, your formal medical training is finally complete. Have a look… Some dedicated doctors spend their whole life for the welfare of the economically backward people or for eradication of some deadly diseases like polio, leprosy, etc. Benjamin Spock wrote editions of his famous parenting book Baby and Child Care, where he stressed on how important it was to switch a child’s diet to a vegan one after the age of 2.
The new study, published online Oct. 5 inNeurology, involved more than 1,300 people averaging 73 years of age. About 250 of them had Alzheimers disease, just over 670 had mild cognitive impairment (including memory deficits), and 390 of the participants had no thinking or memory troubles. Everyone took verbal memory tests where they were given 15 words and then asked to recall them, both immediately after and a half-hour later. The researchers also took PET brain scans of each participant, looking for how well they metabolized glucose — the brains primary energy source. Problems in metabolizing glucose (sugar) in the brain is often a hallmark of Alzheimers disease, the study authors explained. http://gotonaomibrooks.pca-plus.com/2016/09/26/emerging-answers-for-effective-programs-of-specialist-training-for-national-health-serviceThe investigators found that women tended to have better verbal memory skills than men — even when their brains had similar problems metabolizing sugar . These results suggest that women are better able to compensate for underlying changes in the brain with their cognitive reserve until the disease reaches a more advanced stage, Sundermann said in a journal news release. If these results are confirmed, adjusting memory tests to account for the differences between men and women may help diagnose Alzheimers disease earlier in women, she concluded. One Alzheimers specialist who reviewed the study suggested that the female edge in verbal memory may fade with time. Women are better at verbal recall than their male peers and this advantage appears to persist even when they develop Alzheimers disease, said Dr.
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